The show, a spin-off of "Cheers," debuted in 1993, starring Kelsey Grammer as the psychiatrist Frasier Crane.
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The series was set in Seattle, where Frasier reconnects with his brother Niles and his father Martin.
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The show's popularity led to a reboot with Grammer reprising his role, alongside new cast members.
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Notable actors considered for roles included John Lithgow and Lisa Kudrow before the final cast was chosen.
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The character Maris Crane, Niles' wife, was intended to appear but proved too challenging to cast due to her unique description.
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"Frasier" remains a beloved and iconic sitcom, celebrated for its wit, humor, and memorable characters.
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